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Sometimes called "Duplicating", Bio-Fission is a term used to describe the ability of some characters to spontaneously replicate their own cellular structure, creating a perfect duplicate of themselves. The number of duplicates that can be created, as well as any caveats to this power differs from person to person.

Often, the duplicates (or duploids) maintain the same memories and personality as their parent host. If one of the duplicates should be killed, it can often lead to disastrous consequences for the host in question. Depending upon the circumstances involved, a duploid may develop its own personality independent from that of the parent host.